Product Description
Ditertiary Butyl Dicarbonate (Boc Anhydride CAS) CAS: 24424-99-5 is a reagent widely used in organic synthesis. Since this compound can be regarded formally as the acid anhydride derived from a tert-butoxycarbonyl (Boc) group, it is commonly referred to as Boc anhydride. This pyrocarbonate reacts with amines to give N-tert-butoxycarbonyl or so-called Boc derivatives. These carbamate derivatives do not behave as amines, which allows certain subsequent transformations to occur that would be incompatible with the amine functional group. The Boc group can later be removed from the amine using moderately strong acids (e.g., trifluoroacetic acid). Thus, Boc serves as a protective group, for instance in solid phase peptide synthesis. Boc-protected amines are unreactive to most bases and nucleophiles, allowing for the use of the fluorenylmethyloxycarbonyl group (Fmoc) as an orthogonal protecting group.
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Product Name: |
Di-tert-butyl dicarbonate； Di-tert-butyl pyrocarbonate; di(tert-butyl) carbonate; di-t-Butyl-dicarbonate Dicarbonic acid, bis(1,1-dimethylethyl)ester; (t.-Boc)2O; DIBOC; Dibutyldicarbonate; BOC anhydride; BOC-20; Di-t-butyl pyrocarbonate; Di-tert butyl dicarbonate; |
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CAS: |
24424-99-5 |
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EINECS: |
246-240-1 |
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MF:(molecular formula) |
C10H18O5 |
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MW:(molecular weight) |
218.25 |
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MOL File: |
24424-99-5.mol |
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InChI |
InChI=1/C3Cl6O3/c4-2(5,6)11-1(10)12-3(7,8)9 |
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Di-tert-butyl dicarbonate cas:24424-99-5 Chemical Properties |
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Melting point |
23 °C (lit.) |
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Boiling point |
84.6°C at 760 mmHg |
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Density |
0.95g/mLat25°C(lit.) |
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Flashing point |
99°F |
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Water solubility |
Miscible with decalin, toluene, carbon tetrachloride, tetrahydrofuran, dioxane, alcohols, acetone, acetonitrile and dimethylformamide. Immiscible with water. |
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Vapor pressure |
0.7mmHg at 25°C |
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Refractive index |
n20/D1.409(lit.) |
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Storage temp. |
2~8°C |
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Form |
solid or liquid /Low Melting Crystalline Solid |
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Color |
White |
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Sensitive |
Moisture Sensitive |
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BRN |
1911173 |
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InChIKey |
DYHSDKLCOJIUFX-UHFFFAOYSA-N |
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CAS DataBase Reference |
32315-10-9 (CAS DataBase Reference) |
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EPA Substance Registry System |
Dicarbonic acid, bis(1,1-dimethylethyl) ester (24424-99-5) |
Ditertiary Butyl Dicarbonate (Boc Anhydride CAS) CAS: 24424-99-5 is a new type of amino protective agent, which is used to introduce tert-butoxycarbonyl (BOC) protective agent in organic synthesis, especially for amino protection of amino acids.
It is widely used in the synthesis of pharmaceuticals, protein and peptide synthesis, biochemistry, food, cosmetics and many other products. The finished product is colorless crystal or colorless liquid, melting point 22~23 ℃, boiling point 56~57 ℃/66 Pa, refractive index (ND20) 1.409, relative density 0.950. It is soluble in organic solvents such as tetrahydrofuran, hexane, benzene and trichloromethane, and slightly soluble in water. English name: Di- tert- butyl dicarbonate, C.A Naming and registration number: Dicarbonic acid, bis ( 1, 1-dimethylethyl) ester, [24424-99- 5].
How Much Do You Know About Di-tert-butyl Dicarbonate?
● High purity >99%
● Stable supply capability: 1000tons/Year
● Standard packaging and storage
● Warranty: if there are quality problems, we can negotiate a refund or exchange
● Used as intermediates of pharmaceutical and organic synthesis, it is an important aminoprotectant used in the synthesis of pharmaceutical and agrochemical products.
● As a reagent to introduce Boc protecting group for the amine functionalities.
● To prepare tert-butyl ethers and Boc-alcohols in presence of Lewis acid catalyst.
● As a carboxylating agent for the preparation of a variety of tert-butyl carboxylates.
● For the conversion of amines to corresponding isocyanates, carbamates and urea derivatives.
● As a coupling reagent for anchoring various carboxylic acids to hydroxymethylated resins.
● To synthesize quinolinones and 2-(pseudo)haloquinolines from 2-alkenylanilines in presence of DMAP as a catalyst.
● Protection of alcohols as Boc derivatives via Lewis acid catalysis.
● Reagent for the introduction of the Boc protecting group.
● Tris-Boc protected hydrazine allows preparation of Fmoc ester in a chromophoric reagent to monitor solid-phase aldehydes.
● Aminomethyl allene was prepared by reaction of Boc propargyl amine with formaldehyde, diisopropylamine and copper bromide as part of a series of Bovine Plasma Amine Oxidase inactivators.
● Reagent for the preparation of Boc protected amines.
-Our Policy "We care quality, we care life"
-Delivery: By air or sea (DHL,UPS, FeDex,TNT...)
-Warranty information: if there are quality problems, we can negotiate a refund or exchange
● Main markets
● North America includes the United States, Canada, and Mexico
● Europe includes Belgium, Germany, France, UK, Italy, Spain
● South America includes Colombia, Argentina, Brazil, and Chile
● The Asia Pacific includes Japan, China, Korea, India, Saudi Arabia, and Southeast Asia
● What exhibitions have we participated
● API 2017 2018 2019 2022 online, China,Germany, Japan
FAQ about Di-Tert-Butyl Dicarbonate
TT/ LC/Paypal,Western Union...
Di-Tert-Butyl Dicarbonate Packing In 25kgs or 30kgs net plastic drum, or steel drum, according to customer's requests.
● Dispose of under dry protective gas at 2-8℃.
● Keep the receptacle sealed, put it into a tight receptacle and store in a cool, dry place.
Boze Chemical frequently reviews storage conditions to optimize them. Please note that the latest information on the storage temperature for the products is described on our website.
To send your quote request for bulk quantities, please click on the "Request Quote" button.
● Dangerous Goods Mark: T+, T, F, Xi, F+
● Hazardous category code: 11-19-26-36/37/38-43-10-40
● Safety Description: 16-26-28-36/37-45-7/9-37/39-24-36/37/39-33
● Dangerous Goods Transport Number: UN29296.1/PG1
● WGKGermany: 3
● RTECS No.: HT0230000
● F: 4.4-10-21
● Self-ignition temperature: 460°C
● Hazard Note: Flammable/Irritant/VeryToxic
● TSCA: Yes
● HazardClass: 6.1
● PackingGroup: I
● Toxicity: LD50orallyin Rabbit:>5000mg/kg LD50dermal Rabbit>2000mg/kg
●Bottles of di-tert-butyl dicarbonate buildup of internal pressure in sealed containers caused by its slow decomposition to di-tert-butyl carbonate and ultimately tert-butanol and CO2 in the presence of moisture. For this reason, it is usually sold and stored in plastic bottles rather than glass ones.
●Hydrolyzes to t-butanol and CO2; causes internal pressure in bottle if exposed to moisture.
